Ultrasound-promoted synthesis of 3-trichloromethyl-5-alkyl(aryl)-1,2,4-oxadiazoles
نویسندگان
چکیده
منابع مشابه
Synthesis of N, N΄3, 4-Dialkylamino-1, 2, 5-Oxadiazoles
N, N΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of N, N΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚C. Under similar conditions N, N΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and N, N΄-3, 4-di(isopropylamino)...
متن کاملsynthesis of n, n΄3, 4-dialkylamino-1, 2, 5-oxadiazoles
n, n΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of n, n΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚c. under similar conditions n, n΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and n, n΄-3, 4-di(isopropylamino)-1, 2, 5-oxadiazole (1e) were not obtained, but, n, n΄-3, 4-di(ethylamino)-1, 2, 5-oxadiazole (1g) was appeared with smal...
متن کاملSynthesis and anticancer activity of novel 5-(indole-2-yl)-3-substituted 1,2,4-oxadiazoles.
A new series of 5-(indole-2-yl)-3-substituted 1,2,4-oxadiazoles were synthesized and evaluated for their anticancer activities. Structures of the compounds were confirmed by spectroscopic methods. Structural modifications were done to improve the antiproliferative activity of compound 1. The results indicated that a benzyloxyl substituent on the C-4 position was better than a methyl substituent...
متن کاملReaction of 2 , 5 - Disubstituted - l , 3 , 4 - oxadiazoles
Some 5-aryl-2-mercapto-1,3,4-oxadiazole (I) reacted with maleic anhydride, maleic acid and p-benzoquinone affording 2-(5-aryl-1,3,4-oxadiazol-2-ylthio)succinic anhydrides (II), 2-(5-aryl-1,3,4-oxadiazol-2-ylthio)succinic acids (III) and 2-(2,5-dihydroxyphenylthio)-5-aryl-l,3,4-oxadiazoles (IV), respectively. Treatment of 2-methylthio-5-phenyl-l,3-oxadiazole (V) with amines gives 2-[(alkyl or ar...
متن کامل3-Glucosylated 5-amino-1,2,4-oxadiazoles: synthesis and evaluation as glycogen phosphorylase inhibitors
Glycogen phosporylase (GP) is a promising target for the control of glycaemia. The design of inhibitors binding at the catalytic site has been accomplished through various families of glucose-based derivatives such as oxadiazoles. Further elaboration of the oxadiazole aromatic aglycon moiety is now reported with 3-glucosyl-5-amino-1,2,4-oxadiazoles synthesized by condensation of a C-glucosyl am...
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ژورنال
عنوان ژورنال: Ultrasonics Sonochemistry
سال: 2011
ISSN: 1350-4177
DOI: 10.1016/j.ultsonch.2010.09.016